I'm considering buying an old Creamware Pulsar 2 card or some kind of Sonic Core card (the 14 DSP card looks nice

I've spent some time reading through some threads at this forum and I've seen people recommending a PC setup based on an Intel processor + suitable motherboard. Is this just out of personal preference or is Intel in fact to be recommended when using Creamware/Sonic Core cards? How about when it comes to audio processing in general? Is Intel to be preferred there as well for any reason? Anyone got any facts? All I know right now is that a couple of years ago there was a family of Intel processors that performed very badly in audio applications such as Cubase due to problems computing very small float numbers (which is common in audio software environments). Is this ancient history and Intel is just as a good alternative as AMD or even better when it comes to high-end audio processing?
Since I'm going to get me a new studio computer and would like to get me as much performance as possible it would be nice if the best performing processor+motherboard out there also would be compatible with Creamware/Sonic Core cards. So I wouldn't have to choose some lesser processor+motherboard just because the Creamware/Sonic Core card works better that way. Any comments on this? Any families or particular models of processors+motherboards that I definitely should stay clear of? Intel Core2Duo? Intel Core2Quad? AMD Athlon 64? AMD Athlon 64 X2?
Just some general concerns. All help is appreciated.
Thanks,
Tomas